Figure 1

Effect of DHA treatment on histological alterations of the spinal cord tissue 24 h after injury and on hind limb motor disturbance. No histological alterations have been found in the spinal cord tissue collected from sham-operated mice (A, see histological score D). A significant damage to the spinal cord was assessed in SCI-operated mice stained with H & E (B see histological score D). The treatment with DHA resulted in a significant decrease in the extent and severity of the histological signs (C, see histological score D). Moreover, the degree of motor disturbance was assessed every day until 10 days after SCI by Basso mouse scale (BMS) open-field score. Treatment with DHA administered 30 min after trauma reduces the motor disturbance after SCI (E). This figure is representative of at least three experiments performed on different experimental days. ND: not detectable. Values shown are mean ± SEM of ten mice for each group; *P < 0.01 vs sham; °P < 0.01 vs SCI.