RIG-1 is elevated in the temporal cortex of mild cognitive impairment (MCI) patients. Representative immunoblots (A) of the temporal cortex (B) and occipital cortex (C) from age-matched controls (NCI), MCI and Alzheimer Disease (AD) patients analyzed for RIG-1 expression. β-actin was used as a protein loading control and internal standard. Data are presented as mean ± SEM. *P < 0.05. N = NCI: 22, MCI: 20 and AD: 23.