PD168393 reduced demyelination after spinal cord injury (SCI). A 15 mm length of spinal cord centered at the injury site was harvested at day 28 post-injury and serially sectioned (n = 5/group). Representative transverse Luxol Fast Blue stained sections at the epicenter and in 1 mm increments rostral and caudal to the epicenter. Epicenter sections are indicated by arrows. Scale bar = 1 mm (A). Graphical representation shows statistically significant reduction in lesion cavity volume following PD168393 treatment as well as considerable decrease in myelin loss (B) (n = 5, *P < 0.05 compared to control).