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Figure 7 | Journal of Neuroinflammation

Figure 7

From: Toll-like 4 receptor inhibitor TAK-242 decreases neuroinflammation in rat brain frontal cortex after stress

Figure 7

Anti-inflammatory effects of systemic TAK-242 after stress exposure in rat brain frontal cortex. Western blot detection of the pro-inflammatory enzymes (A) inducible cyclooxygenase (COX-2) and (B) inducible nitric oxide synthase (iNOS), and densitometric analysis of the respective bands of interest in brain cortex samples from control (CONTROL) and stressed rats with TAK-242 (S(TAK)) or without TAK-242 (STRESS). The densitometric data of the respective band of interest are normalized by β-actin (lower band). In A and B, the data are representative of two experiments (n = 3 to 4 per group in each experiment). One-way analysis of variance followed by Newman–Keuls post hoc test. *P < 0.05 versus control; # P < 0.05 versus stress. O.D., optical density. (C) IL-1β mRNA relative levels in brain frontal cortex samples of control and stressed rats with or without TAK-242 (S(TAK) and STRESS, respectively). mRNA data are normalized by tubulin. Data represent the mean ± SEM (n = 4 to 5 per group). One-way analysis of variance followed by Newman–Keuls post hoc test. *P < 0.05 versus control # P < 0.05 versus stress.

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