Figure 6
Progression of pathological hallmarks in APP SL mice over age. Graphs represent percent change of markers normalized to the values of age-matched non-transgenic littermates. Six-month-old non-transgenic littermates serve as baseline to show the change at the onset age. The maximum change during the investigated age span is set to 100%. Thus data display the dynamics of amyloid fiber load (LOC), activated microgliosis (CD11b), astrogliosis (GFAP) and lipid peroxidation (TBARS) for the neocortex (A) and the hippocampus (B). Abbreviations: glial fibrillary acidic protein: GFAP, thiobarbituric acid reactive substances: TBARS, amyloid beta: Aβ, Amyloid Precursor protein carrying the Swedish London mutation: APPSL.