Figure 1

Effect of gp120 on the mRNA levels of (A) IL-1β, (B) iNOS and (C) TNF-α in different brain regions of ICV-administered gp120 (500 ng) rats along with a CCR5 antagonist, maraviroc (MVC). Wild-type (no surgery), control (saline) and heat-inactivated (HI) gp120-injected animals were also analyzed. Results are expressed as mean ± SEM (n = 10 for saline and gp120 groups; n = 3 for wild-type, HI gp120 and maraviroc-treated groups). Asterisks represent data points significantly different from saline-administered animals (***P <0.001; **P <0.01; *P <0.05). (gp120 = glycoprotein120; IL-1β = interleukin-1β; iNOS = inducible nitric oxide synthase; TNFα = tumor necrosis factor-α; ICV = intracerebroventricular; MVC = Maraviroc; HI = heat inactivated).