Figure 2

ELISA analysis of (A) IL-1β and (B) TNF-α secretion in the CSF of gp120 (500 ng) administered rats in the presence of maraviroc (MVC). CSF collected from saline- and heat-injected animals were used as control. Results are expressed as mean ± SEM (n = 10 for saline and gp120 groups; n ≥3 for wild-type, HI gp120 and maraviroc-treated groups). Asterisks represent data points significantly different from saline-administered animals (***P <0.001; **P <0.01). (ELISA = Enzyme linked immunoabsorbant assay; IL-1β = interleukin-1β; TNFα = tumor necrosis factor-α; CSF = cerebrospinal fluid; gp120 = glycoprotein120; MVC = Maraviroc; HI = heat inactivated).