Figure 4

Immunoblot (upper panel) and densitometric analysis (lower panel) of drug efflux transporters (P-gp, Mrp1 and Bcrp) in (A) frontal cortex, (B) hippocampus and (C) striatum of ICV-administered gp120 rats. Transporter over-expressing cell lines were used as positive controls. Representative blots are shown. Results are expressed as mean ± SEM. Samples obtained from six different animals were used per group. Asterisks represent data points significantly different from saline-administered animals (**P <0.01; * P <0.05). (P-gp = P-glycoprotein; Mrp1 = multidrug resistance protein 1; Bcrp = breast cancer resistance protein; ICV = intracerebroventricular; gp120 = glycoprotein120).