Figure 4

Loss of synaptic markers following Aβ infusion. WT and IL1raKO mice were infused with Aβ or vehicle, and brains prepared as in Figure 2. A) Aβ-infused mice had reduced hippocampal PSD-95 levels compared to vehicle-infused mice, and there was a significantly larger decrease in IL1raKO mice infused with Aβ versus their WT counterparts (error bars = SEM; * p < 0.05). B) The presynaptic marker synaptophysin was reduced in Aβ-infused mice compared to the vehicle-infused mice. In addition, the reduction in synaptophysin in Aβ-infused mice was greater in IL1raKO mice compared to WT mice, although the difference did not quite reach statistical significance (error bars = SEM; p = 0.07).