Table 1 Effect of different doses of the cyclooxygenase-2 inhibitor nimesulide on total, cortical and subcortical infarct volumes in a rat model of permanent focal cerebral ischemia.

Repeated doses

Vehicle (n = 9)

56.1 ± 11.4

41.6 ± 10.3

12.6 ± 4.5

Nimesulide 3 mg/kg (n = 7)

54.9 ± 14.9

38.1 ± 17.2

14.3 ± 2.4

Nimesulide 6 mg/kg (n = 8)

41.4 ± 12.3

31.8 ± 9.3

9.7 ± 3.5

Nimesulide 12 mg/kg (n = 9)

34.1 ± 13.8 **

24.6 ± 11.2 **

7.1 ± 3.9 *

Single dose

Vehicle, single dose (n = 7)

55.2 ± 15.5

43.9 ± 10.9

13.2 ± 4.2

Nimesulide 12 mg/kg, single dose (n = 8)

49.5 ± 11.7

39.4 ± 11.8

9.1 ± 3.1^&