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Table 1 Effect of different doses of the cyclooxygenase-2 inhibitor nimesulide on total, cortical and subcortical infarct volumes in a rat model of permanent focal cerebral ischemia.

From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat

Treatment Total infarct volume (%) Cortical infarct volume (%) Subcortical infarct volume (%)
Repeated doses    
Vehicle (n = 9) 56.1 ± 11.4 41.6 ± 10.3 12.6 ± 4.5
Nimesulide 3 mg/kg (n = 7) 54.9 ± 14.9 38.1 ± 17.2 14.3 ± 2.4
Nimesulide 6 mg/kg (n = 8) 41.4 ± 12.3 31.8 ± 9.3 9.7 ± 3.5
Nimesulide 12 mg/kg (n = 9) 34.1 ± 13.8 ** 24.6 ± 11.2 ** 7.1 ± 3.9 *
Single dose    
Vehicle, single dose (n = 7) 55.2 ± 15.5 43.9 ± 10.9 13.2 ± 4.2
Nimesulide 12 mg/kg, single dose (n = 8) 49.5 ± 11.7 39.4 ± 11.8 9.1 ± 3.1&
  1. Data are mean ± S.D. * P < 0.05 and ** P < 0.01 compared to vehicle. One-way ANOVA followed by Student-Newman-Keuls post-hoc test. &P < 0.05 compared to vehicle single dose (Student's t-test).