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Table 2 Effect of different doses of nimesulide on neurological deficits and functional outcome (evaluated using the rotarod test) following permanent middle cerebral artery occlusion in the rat.

From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat

Treatment

Neurological Score

Rotarod performance (% of presurgery levels)

Sham-operated control (n = 8)

0

128 ± 21

Repeated doses

  

Vehicle (n = 9)

3 (3–5)

49 ± 18

Nimesulide 3 mg/kg (n = 7)

3 (2–4)

64 ± 13

Nimesulide 6 mg/kg (n = 8)

2 (1–5) *

89 ± 20 **

Nimesulide 12 mg/kg (n = 9)

2 (1–4) **

84 ± 14 **

Single dose

  

Vehicle, single dose (n = 7)

3 (3–5)

43 ± 21

Nimesulide 12 mg/kg, single dose (n = 8)

3.5 (2–5)

52 ± 19

  1. Values show the median and range (neurological score) and means ± S.D. (rotarod performance). For the analysis of neurological score data, the Kruskal-Wallis nonparametric ANOVA followed by Dunn test (multiple comparison) or Mann-Whitney test for analysis of individual differences were used. For the statistical analysis of rotarod performance results, ANOVA followed by Student-Newman-Keuls post-hoc test was employed. * P < 0.05 and ** P < 0.01 compared to vehicle.
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Journal of Neuroinflammation

ISSN: 1742-2094