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Table 2 Effect of different doses of nimesulide on neurological deficits and functional outcome (evaluated using the rotarod test) following permanent middle cerebral artery occlusion in the rat.

From: Effects of the cyclooxygenase-2 inhibitor nimesulide on cerebral infarction and neurological deficits induced by permanent middle cerebral artery occlusion in the rat

Treatment Neurological Score Rotarod performance (% of presurgery levels)
Sham-operated control (n = 8) 0 128 ± 21
Repeated doses   
Vehicle (n = 9) 3 (3–5) 49 ± 18
Nimesulide 3 mg/kg (n = 7) 3 (2–4) 64 ± 13
Nimesulide 6 mg/kg (n = 8) 2 (1–5) * 89 ± 20 **
Nimesulide 12 mg/kg (n = 9) 2 (1–4) ** 84 ± 14 **
Single dose   
Vehicle, single dose (n = 7) 3 (3–5) 43 ± 21
Nimesulide 12 mg/kg, single dose (n = 8) 3.5 (2–5) 52 ± 19
  1. Values show the median and range (neurological score) and means ± S.D. (rotarod performance). For the analysis of neurological score data, the Kruskal-Wallis nonparametric ANOVA followed by Dunn test (multiple comparison) or Mann-Whitney test for analysis of individual differences were used. For the statistical analysis of rotarod performance results, ANOVA followed by Student-Newman-Keuls post-hoc test was employed. * P < 0.05 and ** P < 0.01 compared to vehicle.