Inhibition of NF-κB activation by 5-lipoxygenase inhibitors protects brain against injury in a rat model of focal cerebral ischemia

Table 2 Infarct volume, infarct area and neurological score in untreated (vehicle) and 5-LOX inhibitor-treated rats at 24 h reperfusion after 20 min MCAO.

A.Infarct volume and infarct area
	Group	N	Infarct volume (mm ³ )	Infarct area (%)
	Vehicle	7	522.5 ± 11.2	41.3 ± 10.5
	Caffeic acid	7	229.5 ± 18.5*	12.8 ± 1.9*
	AA-861	7	210.4 ± 20.5*	11.3 ± 2.9*
	BW-B 70C	7	205.2 ± 8.9*	11.8 ± 2.1*
B. Neurological Score	Number of animals = 7
	Vehicle	Caffeic acid	AA-861	BW-B 70C
	Frequencies
0	0	0	0	0
1	0	4	4	5
2	0	3	2	2
3	6	0	1	0
4	1	0	0	0
Median	3	1	1	1

Infarct volume and infarct area (A) and neurological deficit score (B) were measured at 24 h of reperfusion after 20 min MCAO. Animals were treated either with 5-LOX inhibitors dissolved in DMSO alone (vehicle) at reperfusion as described in Methods. Data in Table B represent number of animals showing corresponding neurological score (ranging from 0 to 4 as detailed in Methods). Data are expressed as mean ± SD for infarct area and infarct volume and as range and median for neurological deficit score. *p < 0.001 vs. vehicle.

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