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Figure 1 | Journal of Neuroinflammation

Figure 1

From: Boosting with intranasal dendrimeric Aβ1–15 but not Aβ1–15 peptide leads to an effective immune response following a single injection of Aβ1–40/42 in APP-tg mice

Figure 1

Anti-Aβ antibodies are produced by priming with Aβ1–40/42, followed by boosting with Aβ40/42 or dAβ1–15. J20 APP-tg mice primed with a single subcutaneous dose of Aβ1–40/42 with LT(R192G) and subsequently boosted intranasally with Aβ1–40/42 (n = 6) or dAβ1–15 (n = 7) produce anti-Aβ antibodies. However, J20 APP-tg mice receiving adjuvant alone (n = 6) or boosted with Aβ1–15 peptide (n = 8) did not produce any detectable antibodies. Wildtype littermates immunized with a priming dose of Aβ1–40/42 and boosted with dAβ1–15 (n = 4) generated significantly higher levels of anti-Aβ antibodies compared to any of the immunized J20 APP-tg mice regardless of treatment group (*p < 0.05, Kruskal-Wallis one-way ANOVA). Wildtype mice immunized by dAβ1–15 alone (n = 4) produced high levels of anti-Aβ antibodies that were significantly greater than those produced by APP-tg mice primed with Aβ1–40/42 and boosted with Aβ1–15 and vehicle controls (**p < 0.05, Kruskal-Wallis one-way ANOVA). Mean ± SEM.

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Journal of Neuroinflammation

ISSN: 1742-2094