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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Leader (L) and L* proteins of Theiler's murine encephalomyelitis virus (TMEV) and their regulation of the virus' biological activities

Figure 2

TMEV genome and two different initiation sites. All the TMEVs have an authentic initiation site at nucleotide (nt) 1066, from which the polyprotein is translated followed by cleavage into L, P1, P2 and P3. DA subgroup strains synthesize a small 17–18 kDa protein, L*, from an alternative, out-of-frame, initiation site, which is located at nt 1079. In contrast, GDVII subgroup strains or DAL*-1 virus do not synthesize L* since the L* initiating AUG is replaced with ACG.

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Journal of Neuroinflammation

ISSN: 1742-2094