Figure 2
From: Expression profiles for macrophage alternative activation genes in AD and in mouse models of AD
Alternative activation genes in mouse models of amyloid pathology. The transcripts of activation-related genes were measured in cortical extracts from Tg-2576 (AD model) and Tg-SwDI mice (CAA model) using quantitative RT-PCR. The data are presented as the average (± SEM) fraction of control levels where the appropriate aged-matched wild type littermate mice served as the comparator control. A.Tg-2576 mice- mRNA for TNFα (p < 0.01), AGI (p = 0.05), MRC1 (p < 0.01), and YM1 (p < 0.02) were significantly increased in the Tg-2576 mice brain B. Tg-SwDI mice- Only TNFα mRNA levels were significantly increased (p < 0.05) in Tg-SwDI mouse brain.