Figure 6

Selective COX-2 inhibitors alleviate MPTP-induced loss of spontaneous locomotor activity of C57BL/6 mice. On pre-MPTP days (A), there were no statistically significant differences among the experimental groups in the total distance (cm) mice traveled during each 30-min session. By the end of the pre-MPTP treatment period (3 days before MPTP injection), mice in all groups traveled similar distances. MPTP was administered at day zero. After MPTP treatment (B), mice initiated less spontaneous locomotor activity than they had prior to MPTP administration. On average, valdecoxib-treated mice performed up to 25% better than the vehicle-treated mice. Data are means ± SEM for eight to twelve mice per group pre-MPTP treatment and six to eight mice per group post-MPTP treatment. Statistical significance was assessed by two-way repeated measures ANOVA with Bonferroni post hoc test, **p < 0.01 and ***p < 0.001 compared to the saline+vehicle group; ##p < 0.01 compared to MPTP+vehicle group.