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Table 2 IFN-γ treated neurons show increased sensitivity to HuPrP82-146. Neurons treated with 1 ng/ml IFN-γ for 24 hours prior to the addition of neurotoxins as shown. Cell survival was determined 24 hours later using the WST-1 test. Each value is the mean percentage cell survival ± SD from triplicate experiments repeated 3 times (9 observations). ** = Neuronal survival significantly less than untreated neurons incubated with HuPrP82-146 (p < 0.05).

From: Interferon-γ increases neuronal death in response to amyloid-β1-42

   Neuronal survival (%)
  conc Control IFN-γ
HuPrP82-146 (μM) 40 48 ± 6 12 ± 7**
  10 64 ± 5 22 ± 8**
  2.5 92 ± 9 41 ± 9**
Staurosporine (ng/ml) 20 37 ± 4 40 ± 6
  5 78 ± 6 72 ± 8
  1.25 92 ± 3 95 ± 4
Hydrogen peroxide (μM) 1 22 ± 5 18 ± 7
  0.25 58 ± 7 55 ± 6
  0.06 87 ± 6 89 ± 9