Figure 1

Effect of the CRF-like peptide UCN on indices of nigrostriatal damage induced by intranigral injection of LPS. Data were taken from rats 14 days after injection of LPS and UCN except where indicated (7 d post LPS) in which case UCN was given seven days after LPS injection. In some experiments rats were culled seven days after administration of LPS alone to indicate the development of lesion severity at this point. Indices assessed were as follows: upper panel, circling behaviour in response to the DA agonist apomorphine (one way ANOVA F = 7.763, p < 0.001); middle panel, nigral tissue DA concentration (F = 22.77, p < 0.001), lower panel, nigral tissue TH activity (F = 11.47, p < 0.001). Each group comprised 6–8 rats. In each case differences between groups were assessed using Bonferonni's multiple comparison test. *p < 0.05 versus groups treated with either LPS and vehicle or LPS and UCN III.