Figure 2

Lectin staining for microglia in the hippocampus (A–E) and cerebral cortex (F) of rabbits receiving cholesterol diets. The figure shows focal microglial activation evident as hyperintense spots (arrows in A, B, D), and a more diffuse pattern covering most the dentate hilus (asterisks in C). The arrowhead in panel B points to small spot of activated microglia in the CA1 pyramidal layer. Animals receiving drinking water supplemented with aluminum did not show significant microglial activation (E). None of the cholesterol-fed animals showed microglial activation in the cerebral cortex (F). Scale bar: 1,000 μm