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Table 2 Effects of cytokines on BDNF and NT3 gene expression: comparison of gene array and QRT-PCR results

From: Differential effects of Th1, monocyte/macrophage and Th2 cytokine mixtures on early gene expression for glial and neural-related molecules in central nervous system mixed glial cell cultures: neurotrophins, growth factors and structural proteins

ACCESSION ID

GENE

TREATMENT

FOLD CHANGE

   

6 hr array

6 hr PCR

Al030286, X67108

BDNF

Th1 cytokines

-4.19

-1.14

  

MM cytokines

no change

1.09

  

Th2 cytokine

2.11

2.08

E03082

NT3

Th1 cytokines

-4.15

-2.5

  

MM cytokines

-2.71

-1.09

  

Th2 cytokines

-4.73

2.13

  1. CNS glial cultures were treated with the cytokine mixtures and analyzed by Affymetrix gene array or QRT-PCR, as described in Methods. The gene array values are the averages of 3 experiments; the QRT-PCR values are the averages of 3–5 experiments.
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Journal of Neuroinflammation

ISSN: 1742-2094