Figure 7
From: Cholesterol synthesis inhibitors protect against platelet-activating factor-induced neuronal damage
Squalestatin alters the cellular location of the PAF receptor. (A) Dotblots showing the amounts of PAF receptor in sequential dilutions (log 2 dilutions from neat) of extracts from untreated neurons and neurons treated for 24 hours with 100 nM squalestatin. (B) Western blot showing the amounts of PAF receptors in lipid raft/non-raft fractions from untreated neurons and neurons treated with 100 nM squalestatin. (C) Western blot showing the amounts of β-actin in cell extracts from untreated neurons (Con), or neurons treated with 500 nm simvastatin (Sim) or 100 nM squalestatin (Sq).