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Figure 2 | Journal of Neuroinflammation

Figure 2

From: Repeated administration of the noradrenergic neurotoxin N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine (DSP-4) modulates neuroinflammation and amyloid plaque load in mice bearing amyloid precursor protein and presenilin-1 mutant transgenes

Figure 2

Contextual discrimination in the fear conditioning paradigm. Contextual discrimination in the fear conditioning paradigm in WT and TG mice at 8 months (A) and 11 months (B). Compared with respective WT mice, TG mice show impairment in contextual discrimination, a measure of the percent inactivity during 180 seconds during when mice are placed back in the original environment where foot-shock was first administered. DSP-4 treatment did not modify the level of impairment seen in TG mice. *p < 0.05 vs. respective WT group.

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Journal of Neuroinflammation

ISSN: 1742-2094