Contextual discrimination in the fear conditioning paradigm. Contextual discrimination in the fear conditioning paradigm in WT and TG mice at 8 months (A) and 11 months (B). Compared with respective WT mice, TG mice show impairment in contextual discrimination, a measure of the percent inactivity during 180 seconds during when mice are placed back in the original environment where foot-shock was first administered. DSP-4 treatment did not modify the level of impairment seen in TG mice. *p < 0.05 vs. respective WT group.