Neuronal apoptosis and inflammatory responses in the central nervous system of a rabbit treated with Shiga toxin-2

Table 1 Dosage range of Stx2 and clinical findings

Dose (μg/kg)	neurological symptoms (%)	Diarrhea/occult blood	Body weight loss (%)
0.1	1^a /5 (20)	-~+/-~+	8.0~38.8
0.25	0/4 (0)	+/+	13.2~25.6
0.5	0/4 (0)	+/+	22.0~36.7
1.0	2/4 (50)	+/+	26.7
2.0	5/6 (83.3)	+/+	-^b
4.0	5/6 (83.3)	+/+	-^b

^aTransient gait disturbance was observed on the 4th to 6th day after administration of Stx2.
^bnot measured.

ISSN: 1742-2094