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Figure 3 | Journal of Neuroinflammation

Figure 3

From: The synthetic triterpenoid CDDO-methyl ester modulates microglial activities, inhibits TNF production, and provides dopaminergic neuroprotection

Figure 3

CDDO-Me suppresses production of cytokines with known neurotoxic effects on dopaminergic cultures. BV2 microglia were pre-treated with 100 nM CDDO-Me or DMSO vehicle for 17 hrs before a 4-hr stimulation with LPS (10 ng/mL). Inflammatory cytokine and chemokine production were measured from CM using a 7-plex inflammatory cytokine profile immunoassay from Meso-Scale Discovery on an MSD 2400 plate reader. Values represent mean cytokine production ± SEM. Values were analyzed by two way ANOVA followed by Bonferroni's post hoc. ** denotes significance at p < 0.01, *** denotes significance at p < 0.001.

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Journal of Neuroinflammation

ISSN: 1742-2094