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Figure 2 | Journal of Neuroinflammation

Figure 2

From: VEGF receptor antagonist Cyclo-VEGI reduces inflammatory reactivity and vascular leakiness and is neuroprotective against acute excitotoxic striatal insult

Figure 2

Effects of Cyclo-VEGI on VEGF association with glial cells. (A) Double staining for ED1/VEGF (upper panels) and GFAP/VEGF (lower panels) after 1 d injections of PBS (left panel), QUIN (left middle panel), QUIN with Cyclo-VEGI (right middle panel) and Cyclo-VEGI (right panel). Scale bar = 50 μm. (B) Representative examples of merged staining for VEGFR-1 with ED1 (+)ve microglia. Scale bar = 15 μm. (C) Quantitative analysis for the area density of ED1/VEGF (left bar graph) and GFAP/VEGF (right bar graph). Data are mean ± SEM (n = 5 animals/group). *P < 0.05 compared with PBS-injected group. #P < 0.05 compared with QUIN-injected group.

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Journal of Neuroinflammation

ISSN: 1742-2094