Effects of Cyclo-VEGI on viability of striatal neurons. (A) Time-dependent changes in numbers of NeuN (+)ve neurons with QUIN injection (6 hr, 1 and 7 d) and PBS injection at 7 d. Scale bar = 100 μm. (B) Photomicrographs of NeuN (+)ve neurons (upper row) and Fluoro-Jade B (+)ve degenerating neurons (lower row) in striatum from PBS (left panels), QUIN-injected (left middle panels), QUIN-injected rats with Cyclo-VEGI treatment (right middle panels), and Cyclo-VEGI alone (right panels) at 1 day post-injection. Scale bar represents 60 μm. (C) Quantification of the number of NeuN (+)ve neurons (upper bar graph) and Fluoro-Jade B (+)ve degenerating neurons (lower bar graph) in striatum for the four procedures. FJ; Fluoro-Jade B. Data are mean ± SEM (n = 5 animals/group). *p < 0.05 compared with PBS. #p < 0.05 compared with QUIN-injected rats.