Table 1 Comparison of the effects of NSAIDs on APP secretases. The decrease in BACE1 was detected under inflammatory conditions.
From: Interactions between APP secretases and inflammatory mediators
NSAIDs | activity | α-secretase | β-secretase | γ-secretase |
|---|---|---|---|---|
Ibuprofen | PPARγ activator | ↑(69)↕ (70,71) | ↓ (70,90) | ↓Aβ42/Aβ40 (108) |
Indomethacin | PPARγ activator NFκB inhibitor | ↑ (69) ↕ (71) | ↓ (70,90) | ↓Aβ42/Aβ40 (108) |
Naproxen | PPARγ activator | ? | ↓ (70,90) | ↕ Aβ42/Aβ40 (108) |
Flurbiprofen | NFκB inhibitor | ? | ? | ↓Aβ42/Aβ40 (54,108) |
Aspirin | COX-1 inhibitor | ? | ↕ (90) | ↕ Aβ42/Aβ40 (108) |
Sulindac sulphide | COX-1 inhibitor | ? | ↕ (90) | ↓Aβ42/Aβ40 (108) |
Celecoxib | COX-2 inhibitor | ? | ↕ (70,90) | ↑Aβ42/Aβ40 (56) |
Fenofibrate | PPARα activator | ? | ? | ↑Aβ42/Aβ40 (56) |