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Figure 6 | Journal of Neuroinflammation

Figure 6

From: Suppression of acute proinflammatory cytokine and chemokine upregulation by post-injury administration of a novel small molecule improves long-term neurologic outcome in a mouse model of traumatic brain injury

Figure 6

Minozac attenuates neuronal injury after 28 day recovery following TBI. Mice were subjected to TBI or sham procedure. At 3 hr and 9 hr following TBI, mice were injected with Mzc (5 mg/kg/dose) or saline diluent (VEH). After 28-day recovery, neuronal injury was quantified in each region of the hippocampus based on the morphologic appearance of the NeuN-labeled neurons and a score (1 = normal; 2= moderate injury; 3= severe injury) assigned for each region. Representative sections are shown for sham controls (A), TBI treated with saline vehicle (B) and TBI treated with Mzc (C). Neurons in injured animals treated with saline were shrunken and dystrophic (B) compared to both the injured animals treated with Mzc (C) and sham controls (A). (D) Quantification of the regional injury scores between groups. Data are expressed as median injury score ± IQR of n = 5–7 animals per group. *P < 0.05 vs TBI-VEH by ANOVA. Bar = 100 μm.

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Journal of Neuroinflammation

ISSN: 1742-2094