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Table 1 Parameters of activation in microglia stimulated with necrotic HT22 neurons.

From: Necrotic neurons enhance microglial neurotoxicity through induction of glutaminase by a MyD88-dependent pathway

 

Medium

Necrotic HT22

Cytokine secretion (pg/ml)

  

IL-1β

36.6 ± 16.4

37.5 ± 10.3

TNF

ND

15.2 ± 5.4*

IL-12p40

67.7 ± 5.8

745.7 ± 15.5***

IL-6

188.3 ± 4.3

1735.8 ± 85.2***

NO 2 - (μM)

ND

12.5 ± 1.6***

  1. Microglial cells were left untreated or stimulated with necrotic HT22. IL-1β, TNFα, IL-12p40, IL-6 and NO2- were assayed in the cell supernatant 24 hours after stimulation. ND, non-detectable. *** p < 0.001 and * p < 0.05.
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Journal of Neuroinflammation

ISSN: 1742-2094