Bioluminescence recorded at day 10 correlates strongly with clinical score at day 14. GFAP-luc mice were immunized with MOG35–55 emulsified in CFA plus pertussis toxin. Bioluminescence was recorded in living mice and expressed as fold induction over baseline measured 1 day before immunization. Each dot represents one mouse. The correlation was assessed by Pearson correlation analysis (n = 10 mice). R: correlation coefficient.