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Table 3 Potential interactions between IL6 SNPs and IL10 SNPs in the risk of AD

From: Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Interaction

 

Numbers

 

Adjusted*

synergy factor(95% CI, p)

IL6

× IL10

Controls

AD cases

 

rs1800795 CC

× rs1800896 G+

6153

1557

1.56 (1.02–2.38, 0.04)

rs1800795 CC

× rs1800871 CC

6158

1514

1.25 (0.86–1.80, 0.25)

rs1800795 CC

× rs3024505 T+

6190

1546

1.11 (0.75–1.64, 0.60)

rs2069837 AA

× rs1800896 G+

6126

1437

1.37 (0.89–2.11, 0.16)

rs2069837 AA

× rs1800871 CC

6150

1442

1.63 (1.10–2.41, 0.01)

rs2069837 AA

× rs3024505 T+

6172

1429

1.55 (1.02–2.36, 0.04)

  1. IL6 and IL10 = the genes for interleukin-6 and interleukin-10, respectively; SNPs = single nucleotide polymorphisms; AD = Alzheimer's disease; CI = confidence interval; G+ and T+ group the genotypes, GA+GG and CT+TT, respectively; APOEε4 = apolipoprotein E ε4.
  2. *All analyses controlled for centre, age, gender and APOEε4 genotype.
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Journal of Neuroinflammation

ISSN: 1742-2094