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Table 3 Potential interactions between IL6 SNPs and IL10 SNPs in the risk of AD

From: Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Interaction   Numbers   Adjusted*
synergy factor(95% CI, p)
IL6 × IL10 Controls AD cases  
rs1800795 CC × rs1800896 G+ 6153 1557 1.56 (1.02–2.38, 0.04)
rs1800795 CC × rs1800871 CC 6158 1514 1.25 (0.86–1.80, 0.25)
rs1800795 CC × rs3024505 T+ 6190 1546 1.11 (0.75–1.64, 0.60)
rs2069837 AA × rs1800896 G+ 6126 1437 1.37 (0.89–2.11, 0.16)
rs2069837 AA × rs1800871 CC 6150 1442 1.63 (1.10–2.41, 0.01)
rs2069837 AA × rs3024505 T+ 6172 1429 1.55 (1.02–2.36, 0.04)
  1. IL6 and IL10 = the genes for interleukin-6 and interleukin-10, respectively; SNPs = single nucleotide polymorphisms; AD = Alzheimer's disease; CI = confidence interval; G+ and T+ group the genotypes, GA+GG and CT+TT, respectively; APOEε4 = apolipoprotein E ε4.
  2. *All analyses controlled for centre, age, gender and APOEε4 genotype.