Replication by the Epistasis Project of the interaction between the genes for IL-6 and IL-10 in the risk of Alzheimer's disease

Table 4 Odds ratios of Alzheimer's disease for two IL6 and IL10 SNPs, stratified by each other

Odds ratio of AD for :-	In the subset :-	Numbers		Adjusted* odds ratio of AD (95% CI, p)
		Controls	AD cases
IL6	IL10	AA: 2158	AA: 518	0.86 (0.64–1.15, 0.30)
rs2069837	rs1800871 T+	G+: 348	G+: 87
AA vs G+	IL10	AA: 3099	AA: 724	1.38 (1.06–1.79, 0.02)
	rs1800871 CC	G+: 545	G+: 113
IL10	IL6	CC: 545	CC: 113	0.63 (0.44–0.91, 0.01)
rs1800871	rs2069837 G+	T+: 348	T+: 87
CC vs T+	IL6	CC: 3099	CC: 724	1.08 (0.93–1.25, 0.32)
	rs2069837 AA	T+: 2158	T+: 518

IL6 and IL10 = the genes for interleukin-6 and interleukin-10, respectively; AD = Alzheimer's disease; CI = confidence interval; G+ and T+ group the genotypes, GA+GG and CT+TT, respectively; APOEε4 = apolipoprotein E ε4.
*All analyses controlled for centre, age, gender and APOEε4 genotype.

ISSN: 1742-2094