Possible role of glial cells in the onset and progression of Lyme neuroborreliosis

Table 3 Peak CSF and corresponding serum values (pg/ml) of immune mediators in animals that were inoculated with B. burgdorferi.

MEDIATOR	DR50	EL81	EP51	DH50	CH82
IL-6	(wk-1)	(wk-1)	(wk-1)	(wk-1)	(wk-1)
CSF	17.8 ± 0.4	10 ± 0.9	3.7 ± 0.5	46.9 ± 0.2	2.9 ± 0.7
SERUM	0.7 ± 0.2	0.3 ± 0.05	1 ± 0.2	0	3.9 ± 0.5
IL-8	(wk-1)	(wk-2)	(wk-2)	(wk-1)	(wk-2)
CSF	33.4 ± 4.2	15.7 ± 0.1	21.9 ± 1.0	34.5 ± 0.9	10.9 ± 2.0
SERUM	832.8 ± 75	697.6 ± 86.2	625.6 ± 3.7	3442 ± 149.2	422.4 ± 25
CCL2/MCP-1	(wk-2)	(wk 2)	(wk-3)	(wk-3)
CSF	475.9 ± 25.2	345.6 ± 62.3	404.5 ± 6.8	442.3 ± 6.8	*
SERUM	114.1 ± 6.5	71.8 ± 0.4	106.2 ± 2.8	39 ± 11.2
CXCL13/BLC	(wk-3)	(wk-2)	(wk-4)	(wk-3)
CSF	5500	811.5	779	5317.8 ± 70.5	*
SERUM	300	748	1221	199

The time points at which peak values of various immune mediators (pg/ml) were observed in the CSF and corresponding values found in the serum of B. burgdorferi-infected animals are shown. Data represent the mean ± SD of duplicate determinations, except for CXCL13 in animals DR50, EL81, and EP51, where remaining CSF volume available only permitted a single determination.
* CSF concentrations of CCL2 and CXCL13 for animal CH82 were not significantly elevated with respect to control animals.

ISSN: 1742-2094