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Table 3 Peak CSF and corresponding serum values (pg/ml) of immune mediators in animals that were inoculated with B. burgdorferi.

From: Possible role of glial cells in the onset and progression of Lyme neuroborreliosis

MEDIATOR DR50 EL81 EP51 DH50 CH82
IL-6 (wk-1) (wk-1) (wk-1) (wk-1) (wk-1)
CSF 17.8 ± 0.4 10 ± 0.9 3.7 ± 0.5 46.9 ± 0.2 2.9 ± 0.7
SERUM 0.7 ± 0.2 0.3 ± 0.05 1 ± 0.2 0 3.9 ± 0.5
IL-8 (wk-1) (wk-2) (wk-2) (wk-1) (wk-2)
CSF 33.4 ± 4.2 15.7 ± 0.1 21.9 ± 1.0 34.5 ± 0.9 10.9 ± 2.0
SERUM 832.8 ± 75 697.6 ± 86.2 625.6 ± 3.7 3442 ± 149.2 422.4 ± 25
CCL2/MCP-1 (wk-2) (wk 2) (wk-3) (wk-3)  
CSF 475.9 ± 25.2 345.6 ± 62.3 404.5 ± 6.8 442.3 ± 6.8 *
SERUM 114.1 ± 6.5 71.8 ± 0.4 106.2 ± 2.8 39 ± 11.2  
CXCL13/BLC (wk-3) (wk-2) (wk-4) (wk-3)  
CSF 5500 811.5 779 5317.8 ± 70.5 *
SERUM 300 748 1221 199  
  1. The time points at which peak values of various immune mediators (pg/ml) were observed in the CSF and corresponding values found in the serum of B. burgdorferi-infected animals are shown. Data represent the mean ± SD of duplicate determinations, except for CXCL13 in animals DR50, EL81, and EP51, where remaining CSF volume available only permitted a single determination.
  2. * CSF concentrations of CCL2 and CXCL13 for animal CH82 were not significantly elevated with respect to control animals.