Dose-dependent effects of luteolin in combination with 2 IU of IFN-β upon PHA-dependent production of IL-1β (2A) and TNF-β (2B) in cell culture supernatant. PBMCs derived from MS patients were incubated in the presence of 0.2-50 μM luteolin and 0.2-10 μM luteolin in combination with 2IU IFN-β. Values expressed are a percentage of maximum response (% of control). Data is average mean ± SE of 14 MS patients. Asterisks indicate significant differences between luteolin and luteolin in combination with 2IU of IFN-β, P ≤ 0.05 is significant. Abbrev: Lu = luteolin.