Antiphospholipid antibodies: Paradigm in transition

Table 1 Antigens of antiphospholipid antibodies

Antigen	References
Group 1. Best established & studied
β2GPI	Many, e.g.	29, 48,49
Prothrombin	Many, e.g.	8, 98, 50
Protein C, S	Many, e.g.	93
Annexin V	Many, e.g.	11, 123,124
Group 2. Also accepted but less studied
Thrombin		141
Annexin 2		130, 140
Complement C4, FH		131–133
Kininogens		31, 51,52,143
Kallikrein-related		52,133
FVII/FVIIa		135
Antithrombin III		137,138
Group 3. Pure phospholipids
Cardiolipin (CL)	Many, e.g.	46
PE	Many, e.g.	31
PS, PC, etc.	Many, e.g.	53
Oxidized CL		54,55
Oxidized LDL, other PL.		56–58,147,148
Group 4. Often or sometimes included
Plasmin		128
Tissue factor (TF)		134
TF path. inhibitor (TFPI)		130, 309
TPA		60,129
Platelet activating factor (PAF)		153
CD40/CD40L		154
Group 5. Associated or candidate aPL
CD36		157,158
Thrombomodulin		32
EPCR		61,63
Phospholipase A2		156
Group 6. Implicit under definition
FVIII	Many, e.g.	63–66,141
FX		16
FXI		52,67,155
FXII		68,161

ISSN: 1742-2094