Reagent | Uptake by Purkinje cells | Purkinje cell deatha |
---|---|---|
GK1.5 monoclonal rat anti-CD4+ antibody | Identical to normal rat IgG (See Table 1) | <5% of cellsb |
Unconjugated (free) daunorubicin | No detectable uptake | <5% of cellsb |
GK1.5-daunorubicin immunotoxin | Initial uptake at 4 hours Widespread uptake by 6 hours | 6 hours: <10% of cells 8 hours: 90% of cells |