Figure 3

Effects of NPC transplantation on inflammatory reactivity. (A) Representative staining for microglial responses (Iba-1 marker, upper panels), astroglial responses (GFAP marker, middle panels) and levels of TNF-α (lower panels) in GCL and ML following 10 d intrahippocampal injections of PBS/Aβ_1-42 and 7 d transplantation of NPC/dead NPC. The animal groups (panels, left to right) are for PBS, Aβ_1-42, Aβ_1-42 + NPC, Aβ_1-42 + dead NPC and NPC alone, scale bar represents 100 μm. (B) Quantification of data for Iba-1 (left bar graph), GFAP (middle bar graph) and TNF-α (right bar graph) for the different animal groups (N = 5 animals/group, * denotes p < 0.05 compared with PBS, # denotes p < 0.05 compared with Aβ_1-42).