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Archived Comments for: Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease

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  1. Celastrol is not an epoxide

    Daniel Paris, Roskamp Institute

    21 March 2013

    Celastrol is present in a vine which is widely distributed in eastern and southern China (Tripterygium wilfordii) which is also known in the Chinese language as "Lei Gong Teng" (Thunder God Vine) and has a long history of therapeutic use in traditional Chinese medicine [The Editorial Board of Chinese Materia Medica of State Administration of Traditional Chinese medicine of P. R. China. Chinese Materia Medica; Shanghai Scientific and Technical Publishers: Shanghai, China, 1999; Volume 5, pp. 206:215]. Triptolide and celastrol are known active ingredients of Tripterygium wilfordii. We wrongfully referred celastrol as being an epoxide in the results section of our manuscript. Celastrol is a pentacyclic triterpenoid whereas triptolide is a diterpenoid epoxide.

    Competing interests

    No competing interest.

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