Figure 9
From: Reduction of β-amyloid pathology by celastrol in a transgenic mouse model of Alzheimer's disease
Chronic effects of celastrol on microgliosis in Tg PS1/APPsw mice. A) Representative photomicrographs (taken with a 20× and 60× objective providing a respective magnification of 200× and 600× respectively) depicting the presence of CD45 reactive microglia around Aβ deposits in Tg PS1/APPsw treated with a placebo and celastrol. B) Histogram representing the burden of activated microglia (CD45 positive) in the cortex of Tg PS1/APPsw mice treated with placebo and celastrol pellets. Statistically significant difference in microgliosis burden (P < 0.03) was observed between placebo and celastrol treated mice. (* P < 0.05).