Figure 2

Early increase in serum IL-6 can be used to stratify TBI patients based on risk for developing elevated ICP. A. Time course of ICP in patients classified as having elevated ICP (ICP > 25 mm Hg) versus that recorded in patients whose ICP remained below 20 mm Hg for the duration of the sampling period. B. Standard curve showing the relationship between increasing IL-6 concentrations and the mean fluorescent intensity (MFI) detected by Luminex analysis. C. Summary data showing the levels of IL-6 detected in the serum of healthy volunteers (HV), from TBI patients with elevated ICP (ICP > 25 mm Hg), and from patients whose ICP remained below 20 mm Hg throughout the study period. D. Luminex data organized based on time of sample withdrawal relative to the subsequent increase in ICP. Day 0 represents the time point at which the ICP was recorded to surpass 25 mm Hg. Each patient with an elevation in ICP was paired with a patient whose ICP remained ≤20 mm Hg throughout the study period. Data is presented as mean ± SEM. ‡, significant difference by two-way ANOVA.