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Table 3 Clinical and neuroradiological characteristics of 23 patients with neuromyelitis optica or relapsing myelitis who are seropositive for AQP4 autoantibodies by cell-based IIFA, divided into those who are seropositive and seronegative for NMO-IgG by tissue-based IIFA.

From: Aquaporin-4 autoantibodies in neuromyelitis optica spectrum disorders: comparison between tissue-based and cell-based indirect immunofluorescence assays

  NMO IgG +ve (n = 17) NMO-IgG -ve (n = 6) Significance p value
Female (%) 15 (88%) 6 (100%) ns
Mean onset age in years (range) 42.0 (18-64) 52.8 (17-70) ns
Mean duration of follow-up in years (range) 6.6 (2-15) 3.9 (2-8) ns
Patients with LETM (%) 16 (94%) 6 (100%) ns
Mean myelitis attack rate in no. of attacks per year (range) 0.8 (0.2-2.0) 0.7 (0.3-1.0) ns
Mean myelitis attack rate in first 2 years of disease in no. of attacks per year 1.6 (0.5-3.0) 1.4 (0.5-4.0) ns
Mean length of MRI T2W hyperintense signal abnormalities in no. of vertebral segments (range) 5.3 (2-17) 5.7 (3-10) ns
Patients with MRI brain lesions compatible with inflammatory demyelination (%) 10 (59%) 3 (50%) ns
Patients with CSF OCB (%) 2 (12%) 0 ns
Patients with other autoimmune disorders or autoantibodies (%) 5 (29%) 1 (17%) ns
Patients with poor visual outcome (%) 4 (24%) 1 (17%) ns
Mean EDSS score at latest follow-up (range) 5.9 (2.0-10) 6.8 (6.0-8.0) ns
Patients with poor neurological outcome (%) 11 (65%) 6 (100%) ns
  1. Abbreviations: NMO = neuromyelitis optica, AM = acute myelitis, LETM = longitudinally extensive transverse myelitis, MRI = magnetic resonance imaging, CSF = cerebrospinal fluid, OCB = oligoclonal bands, EDSS = Expanded Disability Status Scale, ns = not significant.