Figure 1

Age-related, Tau Induced CD45 activation. Immunohistochemistry was performed for CD45 in rTg4510 and nontransgenic (nTg) littermates aged 1 (A, B, H, I), 5 (C, D, J, K), and 9 (E, F, L, M) months in the anterior cortex (A-F) and hippocampus (H-M). Panels G and N present mean ± S.E.M of % Area for immunostaining of CD45+ microglia in the anterior cortex and hippocampus, respectively. Statistical analysis was performed using 2-way ANOVA followed by Fisher's PLSD multiple comparison test. Area stained for CD45 significantly increased in rTg4510 mice at 9 months of age in the anterior cortex and hippocampus compared with nontransgenic littermates or with younger mice. Lines above relevant bars display significant differences between groups (*p < 0.05), n = 4-5. Sections were digitized and representative images were taken at 40× magnification. Scale bar represents 50 μm.