Plasma Aβ is increased in 17 month-old PFA1-treated female mice. A. Aβ1-40 levels were measured from plasma collected from vehicle and PFA1 treated 17 month-old female mice before and after 4 weeks of treatment. There was no significant change in plasma Aβ1-40 levels following treatment in vehicle treated animals. There was a trend towards increased Aβ1-40 levels in PFA1-treated female mice (140%) after 4 weeks of treatment. B. Aβ1-42 levels were measured from plasma collected from 17 month-old vehicle and PFA1 treated female mice before and after treatment. There were no significant changes to Aβ1-42 in vehicle-treated animals, but a significant 34% increase (p < 0.05) in PFA1-treated animals following treatment.