Figure 9
CNS MCP-1 is decreased, and is positively correlated with brain Aβ levels, in 17 month-old female mice. A. Levels of inflammatory cytokines MCP-1, IL10, SDF1, and RANTES were measured from brain homogenates of 17 month-old vehicle or PFA1 treated female mice. There were no significant differences in IL10, SDF1, or RANTES between vehicle and PFA1 treated groups. There was a significant 26% (p < 0.05) increase in MCP1 following PFA1 treatment in female mice. B. Correlational analyses were performed between inflammatory cytokines and soluble (DEA) brain Aβ1-40 levels in female mice. MCP1 was significantly positively correlated with soluble Aβ1-40 levels (R2 = 0.4553, p < 0.05). Other cytokines were not significantly correlated with soluble Aβ1-40. C. MCP1 was also significantly correlated with insoluble Aβ1-40 levels (R2 = 0.6149, p < 0.01). Other cytokines were not significantly correlated with insoluble Aβ1-40. D. MCP1 was significantly correlated with the calculated levels of total Aβ1-40 levels (R2 = 0.5835, p < 0.01).