Phagocytosis and LPS alter the maturation state of β-amyloid precursor protein and induce different Aβ peptide release signatures in human mononuclear phagocytes

Table 1 Semiquantitative assessment of Aβ_1-4₀ and Aβ_total by 1D-Aβ-WIB

	CON (n = 21)	Polystyrene beads (n = 15)	acLDL (n = 10)	LPS (n = 11)	Polystyrene beads + LPS (n = 8)
Aβ _1-40 (pg/ml)	1.8 ± 1.3	4.7 ± 2.1**	10.7 ± 6.5***	5.9 ± 5.1**	17.2 ± 14.9***
Aβ _total (pg/ml) ¹	8.5 ± 5.9	17.9 ± 6.6**	28.4 ± 13.8***	18.1 ± 8.5*	43.8 ± 26.9***

Values are expressed as mean ± SD; *P < .05, **P < .01, ***P < .001 compared with CON (Kruskal-Wallis test followed by Dunn's multiple comparison test)
¹ Aβ_total refers to Aβ_{1-38/39/40/42,} Aβ_2-40 and Aβ_2-40^a

ISSN: 1742-2094