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Table 2 Effect of age on inflammatory proteins released by brain microvessels

From: Cerebrovascular expression of proteins related to inflammation, oxidative stress and neurotoxicity is altered with aging

Proteins
(ng/ml)
6
month
12
month
18
month
24
month
IL-1α 1.87 ± 0.31 1.53 ± 0.23 1.13 ± 0.5 0.47 ± 0.12**
MCP-1 12.27 ± 1.22 7.9 ± 5.11 2.97 ± 1.87* 2.07 ± 1.21*
TNFα 7.40 ± 1.91 3.20 ± 1.73* 2.20 ± 0.0** 1.87 ± 0.58**
IFNγ 21.6 ± 1.40 19.67 ± 1.47 14.43 ± 1.78 8.87 ± 5.99**
  1. Microvessels isolated from 6, 12, 18 and 24 month old rat brains were incubated for 8 h in serum-free media and the supernatant centrifuged (12,000 g, 15 min). Proteins released into the supernatant were determined using rat custom 9 plex array ELISA (Pierce Biotechnology, MA). Data are mean ± SD from 3 experiments performed in triplicate. *p < 0.05 vs. 6 month; **p < 0.01 vs. 6 month