Figure 5
IL-1β expression following SE. (A) Saline-infused animal, (B) BzATP-infused animal, (C) OxATP-infused animal. In saline-infused animals, IL-1β-immunoreactive cells are detected in the FPC at 1 day after SE (A1-2). In BzATP-infused animals, IL-1β-immunoreactive microglia are observed at 12 hr after SE (B1-2). In OxATP-infused animals, IL-1β-immunoreactive microglia are observed at 1 days after SE (C1-2). Double immunofluorescent study shows that IL-1β-immunoreactive cells are Iba-1-positive microglia (D1-3). Bar = 50 (panels A, B and C) and 25 (panels D) μm. (D) Quantitative analysis of IL-1β-immunoreactive cells in FPC following SE. Significant differences from saline-infused animals, *P < 0.05 and **P < 0.01.