Figure 10

Deposition of IgG within the myelin sheath of affected fibres. Longitudinal (A) and cross (C) sections of unaffected samples show immunonegative nerve fibres (NF) throughout (empty arrow), whereas inflamed specimens reveal a significant intramyelinic IgG-deposition (B, D; black arrows) in many fibres within (B) or even outside (D) of significantly infiltrated foci. The longitudinal orientation of the nerve fibers is indicated by the double-headed arrow (A). Scale bars = 10 μm (A, B), 15 μm (C, D).