Figure 4

Gf enhancement in circumventricular organs (CVO). Gf distinctly enhanced the choroid plexus and other CVO in naïve control mice and more pronounced after induction of EAE: T1-weighted images of the CVO are shown in axial (row 1) and coronal (row 2-4) orientation. Images were acquired prior to administration of contrast agent (column 1), and 24 h after Gf application in EAE (column 2) and naïve control mice (column 3). Enhancement of the choroid plexus (arrows), the subfornicular organ (square), the organum vasculosum of the lamina terminalis (ovoid), the median eminence (arrowhead) and the area postrema (circle) are clearly marked in the EAE mice (column 2). In naïve mice, only subtle CVO enhancement was detectable (column 3, pins).