From: Characterization of human platelet binding of recombinant T cell receptor ligand
Platelet adhesion (cells/mm2 × 102) | Surface area (μm2) | |||
---|---|---|---|---|
Inhibitor/antagonists | RTL1000 | fibrinogen | RTL1000 | fibrinogen |
vehicle | 44.9 ± 1.1 | 52.8 ± 1.6 | 35.5 ± 3.1 | 31.8 ± 1.2 |
ADP-scavenger/cyclooxygenase inhibitor | 33.4 ± 0.5 | 34.3 ± 0.7 | 34.5 ± 3.9 | 32.1 ± 2.2 |
αIIbβ3 antagonist | 26.4 ± 0.8 | 7.9 ± 1.5 | 17.6 ± 1.8 | 16.7 ± 2.3 |
Src kinase inhibitor | 26.4 ± 0.8 | 48.4 ± 1.9 | 23.7 ± 2.0 | 20.0 ± 1.5 |
Syk kinase inhibitor | 36.1 ± 0.5 | 44.0 ± 0.4 | 19.5 ± 1.9 | 25.0 ± 1.4 |
PI3 kinase inhibitor | 29.0 ± 0.5 | 30.8 ± 0.9 | 26.3 ± 1.7 | 17.3 ± 1.4 |
protein kinase C inhibitor | 36.7 ± 0.5 | 53.7 ± 1.7 | 19.4 ± 2.3 | 27.3 ± 1.6 |
intracellular Ca2+ chelator | 11.4 ± 1.1 | 13.2 ± 1.2 | 15.5 ± 2.1 | 17.2 ± 1.4 |